FUNCTIONAL-ASPECTS OF THE SUPEROXIDE DISMUTATIVE ACTION OF CU-PENICILLAMINE

被引：71

作者：

LENGFELDER, E ^{[1
]}

FUCHS, C ^{[1
]}

YOUNES, M ^{[1
]}

WESER, U ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST PHYSIOL CHEM,D-7400 TUBINGEN 1,FED REP GER

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 567卷 / 02期

关键词：

Cu-penicillamine; Metalloenzyme; Superoxide dismutase;

D O I：

10.1016/0005-2744(79)90135-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide dismutative action of Cu-penicillamine was examined by pulse radiolysis. The second order rate constant of the reaction with superoxide was 0.4 ± 0.2 · 109 M-1 · s-1, comparable to the action of Fe- and Mn-superoxide dismutases. No marked pH-dependence was seen. Neither ethylene diamine tetraacetic acid nor cyanide affected the catalytic action of Cu-penicillamine. The cyanide resistant reactivity as well as further X-ray photoelectron spectrometric measurements supported the suggestion of a Cu(I) stabilized sulphur radical being the active species involved in the catalysis of superoxide dismutation. © 1979.

引用

页码：492 / 502

页数：11

共 30 条

[1] SUPEROXIDE DISMUTASE ACTIVITY OF HUMAN ERYTHROCUPREIN
BANNISTER, JV
BANNISTER, WH
BRAY, RC
FIELDEN, EM
ROBERTS, PB
ROTILIO, G
[J]. FEBS LETTERS, 1973, 32 (02): : 303 - 306
[2] BIRKER PJM, 1976, J CHEM SOC CHEM COMM, V72, P223
[3] STRUCTURE, PROPERTIES, AND FUNCTION OF A COPPER(I)-COPPER(II) COMPLEX OF D-PENICILLAMINE - PENTATHALLIUM(I) MU-8-CHLORO-DODECA(D-PENICILLAMINATO)-OCTACUPRATE(I)HEXACUPRATE(II) NORMAL-HYDRATE
BIRKER, PJMWL
FREEMAN, HC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (21) : 6890 - 6899
[4] SUPEROXIDE-DISMUTASE ACTIVITY OF CU(TYR)2 AND CU,CO-ERYTHROCUPREIN
BRIGELIUS, R
HARTMANN, HJ
BORS, W
SARAN, M
LENGFELDER, E
WESER, U
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1975, 356 (06): : 739 - 745
[5] SUPEROXIDE-DISMUTASE ACTIVITY OF LOW-MOLECULAR WEIGHT CU2+-CHELATES STUDIED BY PULSE-RADIOLYSIS
BRIGELIUS, R
SPOTTL, R
BORS, W
LENGFELDER, E
SARAN, M
WESER, U
[J]. FEBS LETTERS, 1974, 47 (01) : 72 - 75
[6] CRYSTAL STRUCTURE OF BIS(ETHYLENEDIAMINE)COPPER)2) THIOCYANATE
BROWN, BW
LINGAFELTER, EC
[J]. ACTA CRYSTALLOGRAPHICA, 1964, 17 (03): : 254 - &
[7] FIELDEN EM, 1970, MANUAL RAD DOSIMETRY
[8] SUPEROXIDE DISMUTASE ACTIVITY OF CU2+ AMINO ACID CHELATES
JOESTER, KE
JUNG, G
WEBER, U
WESER, U
[J]. FEBS LETTERS, 1972, 25 (01) : 25 - &
[9] JORGENSEN CK, 1974, ADV QUANTUM CHEM, V8, P137
[10] KLUG D, 1972, J BIOL CHEM, V247, P4839

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