SYNTHESIS AND BIOLOGICAL EVALUATION OF (+/-)-Z-HUPERZINE-A

被引：18

作者：

KOZIKOWSKI, AP

YAMADA, F

TANG, XC

HANIN, I

机构：

[1] UNIV PITTSBURGH, DEPT BEHAV NEUROSCI, PITTSBURGH, PA 15260 USA

[2] LOYOLA UNIV, STRITCH SCH MED, DEPT PHARMACOL & EXPTL THERAPEUT, MAYWOOD, IL 60153 USA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)97013-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (±)-Z-huperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. The compound has an IC50 of 6 x 10-6 M, which is comparable to that of huperzine B. © 1990.

引用

页码：6159 / 6162

页数：4

共 7 条

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BARTLETT PA, 1970, TETRAHEDRON LETT, P4459

[2]

KOZIKOWSKI AP, UNPUB J MED CHEM

[3]

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[4]

KOZIKOWSKI AP, 1989, J AM CHEM SOC, V111, P4116

[5]

LIU JS, 1986, ACTA CHIM SINICA, V44, P1035

[6] SELECTIVE PRE-SYNAPTIC CHOLINERGIC NEUROTOXICITY FOLLOWING INTRAHIPPOCAMPAL AF64A INJECTION IN RATS [J].

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[7] EFFECT OF HUPERZINE-A, A NEW CHOLINESTERASE INHIBITOR, ON THE CENTRAL CHOLINERGIC SYSTEM OF THE RAT [J].

TANG, XC ;

DESARNO, P ;

SUGAYA, K ;

GIACOBINI, E .

JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 24 (02) :276-285

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