ASPIRIN-LIKE DRUGS INTERFERE WITH ARACHIDONATE METABOLISM BY INHIBITION OF THE 12-HYDROPEROXY-5,8,10,14-EICOSATETRAENOIC ACID PEROXIDASE-ACTIVITY OF THE LIPOXYGENASE PATHWAY

被引：237

作者：

SIEGEL, MI

MCCONNELL, RT

CUATRECASAS, P

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.3774

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8, 11, 14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid.

引用

页码：3774 / 3778

页数：5

共 28 条

[1] MECHANISM OF ENHANCEMENT BY FATTY-ACID HYDROPEROXIDES OF ANAPHYLACTIC MEDIATOR RELEASE
ADCOCK, JJ
GARLAND, LG
MONCADA, S
SALMON, JA
[J]. PROSTAGLANDINS, 1978, 16 (02): : 179 - 187
[2] ENHANCEMENT OF ANAPHYLACTIC MEDIATOR RELEASE FROM GUINEA-PIG PERFUSED LUNGS BY FATTY-ACID HYDROPEROXIDES
ADCOCK, JJ
GARLAND, LG
MONCADA, S
SALMON, JA
[J]. PROSTAGLANDINS, 1978, 16 (02): : 163 - 177
[3] ALVAN G, 1975, CLIN PHARMACOL THER, V18, P364
[4] CULTURED HUMAN-SKIN FIBROBLASTS AND ARTERIAL CELLS PRODUCE A LABILE PLATELET-INHIBITORY PROSTAGLANDIN
BAENZIGER, NL
DILLENDER, MJ
MAJERUS, PW
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 78 (01) : 294 - 301
[5] INHIBITION OF PLATELET PROSTAGLANDIN SYNTHETASE BY ORAL ASPIRIN
BURCH, JW
STANFORD, N
MAJERUS, PW
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (02) : 314 - 319
[6] INDOMETHACIN AND ASPIRIN ABOLISH PROSTAGLANDIN RELEASE FROM SPLEEN
FERREIRA, SH
MONCADA, S
VANE, JR
[J]. NATURE-NEW BIOLOGY, 1971, 231 (25): : 237 - &
[7] FERREIRA SH, 1978, 7TH P INT C PHARM PA, P420
[8] STIMULATION OF HUMAN EOSINOPHIL AND NEUTROPHIL POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS AND RANDOM MIGRATION BY 12-L-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID
GOETZL, EJ
WOODS, JM
GORMAN, RR
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (01) : 179 - 183
[9] PROSTAGLANDIN ENDOPEROXIDES - NOVEL TRANSFORMATIONS OF ARACHIDONIC-ACID IN HUMAN PLATELETS
HAMBERG, M
SAMUELSS.B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) : 3400 - 3404
[10] PROSTAGLANDIN ENDOPEROXIDES - NEW CONCEPT CONCERNING MODE OF ACTION AND RELEASE OF PROSTAGLANDINS .6.
HAMBERG, M
SVENSSON, J
SAMUELSSON, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) : 3824 - 3828

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