A CONTROLLED CROSSOVER TRIAL OF FENFLURAMINE IN AUTISM

被引：19

作者：

STERN, LM

WALKER, MK

SAWYER, MG

OADES, RD

BADCOCK, NR

SPENCE, JG

机构：

[1] FLINDERS UNIV,MED CTR,BEDFORD PK,SA 5042,AUSTRALIA

[2] ADELAIDE CHILDRENS HOSP INC,ADELAIDE,SA 5006,AUSTRALIA

来源：

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES | 1990年 / 31卷 / 04期

关键词：

autism; event‐related potentials; Fenfluramine; neurotransmitters;

D O I：

10.1111/j.1469-7610.1990.tb00798.x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Abstract We report a 12 month double‐blind randomized crossover trial of fenfluramine in 20 children with the syndrome of autism. On active drug most of the children lost weight and blood serotonin levels fell by an average of 60 %. There was a fall in urinary dopamine (DA) and noradrenaline (NA) levels and increased excretion of homovanillic acid (HVA). Some of the children showed improvement in tests of cognitive and language function, although the results did not achieve overall statistical significance. Event‐related brain potentials (ERPs) were obtained in seven subjects on an auditory choice reaction time task. Side effects of the drug included irritability and lethargy. Fenfluramine may have a limited place in the management of some patients with autistic disorder. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：569 / 585

页数：17

共 66 条

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American Psychiatric Association, 1980, DIAGN STAT MAN MENT, V3rd

[2]

ANDERSON GM, 1981, CLIN CHEM, V27, P775

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