ENZYMATIC METHYLATION OF ALKANE THIOLS

被引:11
作者
HOLLOWAY, CJ
HUSMANNHOLLOWAY, S
BRUNNER, G
机构
关键词
D O I
10.1159/000458680
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A membrane-bound enzymatic activity has been found in rabbit liver microsomes, which catalyses the transmethylation from S-adenosylmethionine to a series of C1-C3 alkane thiols. Methane and ethane thiols are known to be endogenous toxins, which may play an important role in the pathogenesis of hepatic coma, and methylation could provide an important pathway for the metabolic 'detoxification' of this class of compounds through neutralisation of the highly reactive sulph-hydryl group.
引用
收藏
页码:307 / 312
页数:6
相关论文
共 16 条
[1]  
BINKLEY F, 1950, J BIOL CHEM, V186, P287
[2]  
BONSE G, 1978, BIOTRANSFORMATIONEN, P100
[3]   PURIFICATION AND CHARACTERIZATION OF RAT-LIVER MICROSOMAL THIOL METHYLTRANSFERASE [J].
BORCHARDT, RT ;
CHENG, CF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 522 (02) :340-353
[4]   ENZYMIC METHYLATION OF FOREIGN SULFHYDRYL COMPOUNDS [J].
BREMER, J ;
GREENBERG, DM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 46 (02) :217-&
[5]   DIAGNOSTIC VALUE OF DETERMINING SERUM-MERCAPTANS IN LIVER-DISEASE [J].
BRUNNER, G ;
SCHARFF, P .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1978, 103 (45) :1796-1800
[6]   THE METABOLISM OF METHYL MERCAPTAN IN THE INTACT ANIMAL [J].
CANELLAKIS, ES ;
TARVER, H .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1953, 42 (02) :446-455
[7]  
CANELLAKIS ES, 1952, ARCH BIOCH BIOPHYS, V41, P387
[8]   METHYL MERCAPTAN IN RELATION TO FOETOR HEPATICUS [J].
CHALLENGER, F ;
WALSHE, JM .
BIOCHEMICAL JOURNAL, 1955, 59 (03) :372-375
[9]  
DOIZAKI WM, 1977, J LAB CLIN MED, V90, P849
[10]  
FISCHER B, 1976, BIOCH HEPATISCHER EN