ANTINEOPLASTIC AGENTS .107. ISOLATION OF ACTEOSIDE AND ISOACTEOSIDE FROM CASTILLEJA-LINARIAEFOLIA

被引：77

作者：

PETTIT, GR ^{[1
]}

NUMATA, A ^{[1
]}

TAKEMURA, T ^{[1
]}

ODE, RH ^{[1
]}

NARULA, AS ^{[1
]}

SCHMIDT, JM ^{[1
]}

CRAGG, GM ^{[1
]}

PASE, CP ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,CANC RES INST,TEMPE,AZ 85287

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 02期

关键词：

D O I：

10.1021/np50068a026

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant. © 1990, American Chemical Society. All rights reserved.

引用

页码：456 / 458

页数：3

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