5-LIPOXYGENASE IS NOT ESSENTIAL IN MACROPHAGE-MEDIATED OXIDATION OF LOW-DENSITY-LIPOPROTEIN

被引：67

作者：

JESSUP, W ^{[1
]}

DARLEYUSMAR, V ^{[1
]}

OLEARY, V ^{[1
]}

BEDWELL, S ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT BIOCHEM SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1991年 / 278卷

关键词：

D O I：

10.1042/bj2780163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concentration-dependent effects of a series of lipoxygenase inhibitors and antioxidants on the macrophage-mediated oxidative modification of low-density lipoprotein (LDL) were measured. Their influence on macrophage 5-lipoxygenase pathway activity was also studied over the same concentration range. No correlation between inhibition of 5-lipoxygenase and of macrophage-mediated oxidation of LDL was observed. The capacity of the compounds to prevent cell-mediated modification of LDL could be explained in terms of their activity as either aqueous- or lipid-peroxyl radical scavengers. Two potent 5-lipoxygenase inhibitors (MK 886 and Revlon 5901), which had no radical-scavenging properties, were unable to block LDL modification. It is concluded that 5-lipoxygenase is not essential for LDL oxidation by macrophages.

引用

页码：163 / 169

页数：7

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