T-CELL MATURATION AND CLONAL DELETION IN CYCLOSPORINE-INDUCED AUTOIMMUNITY

被引:13
作者
PRUDHOMME, GJ
SANDERS, R
PARFREY, NA
STECROIX, H
机构
[1] MCGILL UNIV,CTR CLIN IMMUNOBIOL & TRANSPLANTAT,MONTREAL H3A 2B4,QUEBEC,CANADA
[2] UNIV ALBERTA,DEPT PATHOL,EDMONTON T6G 2E1,ALBERTA,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1016/0896-8411(91)90030-G
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA 2 strain developed SGVHD. A comparison of the effect of CyA on thymocytic and peripheral T-cell populations revealed that CyA-induced alterations were similar in the two species, although more marked in rats. Notably, CyA-treated syngeneic bone marrow chimeras (SBMC) had transiently increased numbers of peripheral CD4+ CD8+ T-cells, expressing a marker normally limited to thymocytes. Examination of T-cell receptor (TCR) Vβ expression in CyA-treated mice revealed a normal pattern of clonal deletion in all strains (including disease-prone DBA 2 mice), suggesting that CyA may induce autoimmunity without blocking intrathymic clonal deletion. © 1991.
引用
收藏
页码:357 / 368
页数:12
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