EFFECT OF NORADRENERGIC DENERVATION BY NEONATAL DSP-4 ON PEPTIDE NEUROTRANSMITTER SYSTEMS IN THE RAT-BRAIN

被引：6

作者：

DONNERER, J

HUMPEL, C

SARIA, A

机构：

[1] UNIV INNSBRUCK,DEPT PSYCHIAT,NEUROCHEM UNIT,A-6020 INNSBRUCK,AUSTRIA

[2] GRAZ UNIV,DEPT EXPTL & CLIN PHARMACOL,A-8010 GRAZ,AUSTRIA

来源：

NEUROPEPTIDES | 1992年 / 22卷 / 02期

关键词：

D O I：

10.1016/0143-4179(92)90063-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The specific effects of a neonatal treatment of rats with the noradrenergic neurotoxin DSP-4 were investigated in the adult rat by measuring monoamine and peptide transmitter levels in eight brain regions. When applied concomitantly with a 5-hydroxytryptamine uptake blocker, neonatal DSP-4 induced a selective depletion of noradrenaline (NA) in cortex, hippocampus and amygdala. An increase of NA was observed in the medulla and substantia nigra/ventral tegmental area and a decrease in dopamine was observed in the thalamus. The vasoactive intestinal polypeptide levels were markedly elevated in the DSP-4 treated rats in almost all CNS regions whereas those of three other neuropeptides remained unchanged. It is concluded that certain adaptational changes can be observed in the peptide systems of the CNS upon disruption of the development of the noradrenergic innervation.

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页码：103 / 106

页数：4

相关论文

共 14 条

[1] MARKED INCREASES IN CALCITONIN GENE-RELATED PEPTIDE-CONTAINING NERVES IN THE DEVELOPING RAT FOLLOWING LONG-TERM SYMPATHECTOMY WITH GUANETHIDINE [J].

ABERDEEN, J ;

CORR, L ;

MILNER, P ;

LINCOLN, J ;

BURNSTOCK, G .

NEUROSCIENCE, 1990, 35 (01) :175-184

[2] REGION-SPECIFIC NORADRENALINE DEPLETION BY NEONATAL DSP-4 - FUNCTIONAL CONSEQUENCES AND EFFECT ON A COEXISTING NEUROTRANSMITTER [J].

DONNERER, J ;

AMANN, R ;

SKOFITSCH, G ;

LEMBECK, F .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 181 (1-2) :147-150

[3] A QUANTITATIVE STUDY OF NEUROPEPTIDE IMMUNOREACTIVE CELL-BODIES OF PRIMARY AFFERENT SENSORY NEURONS FOLLOWING RAT SCIATIC-NERVE PERIPHERAL AXOTOMY [J].

DOUGHTY, SE ;

ATKINSON, ME ;

SHEHAB, SAS .

REGULATORY PEPTIDES, 1991, 35 (01) :59-72

[4] IMMUNOHISTOCHEMICAL ANALYSIS OF THE NEUROTOXIC EFFECTS OF DSP-4 IDENTIFIES 2 POPULATIONS OF NORADRENERGIC AXON TERMINALS [J].

FRITSCHY, JM ;

GRZANNA, R .

NEUROSCIENCE, 1989, 30 (01) :181-197

[5] INJECTION OF TACHYKININS AND SELECTIVE NEUROKININ RECEPTOR LIGANDS INTO THE SUBSTANTIA-NIGRA RETICULATA INCREASES STRIATAL DOPAMINE AND 5-HYDROXYTRYPTAMINE METABOLISM [J].

HUMPEL, C ;

SARIA, A ;

REGOLI, D .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 195 (01) :107-114

[6] DSP-4 - A NOVEL COMPOUND WITH NEUROTOXIC EFFECTS ON NORADRENERGIC NEURONS OF ADULT AND DEVELOPING RATS [J].

JAIMETCHEVERRY, G ;

ZIEHER, LM .

BRAIN RESEARCH, 1980, 188 (02) :513-523

[7] EFFECTS OF THE NORADRENALINE NEUROTOXIN DSP4 ON THE POSTNATAL-DEVELOPMENT OF CENTRAL NORADRENALINE NEURONS IN THE RAT [J].

JONSSON, G ;

HALLMAN, H ;

SUNDSTROM, E .

NEUROSCIENCE, 1982, 7 (11) :2895-2907

[8] DSP4 (N-(2-CHLOROETHYL)-N-ETHYL-2-BROMOBENZYLAMINE) - A USEFUL DENERVATION TOOL FOR CENTRAL AND PERIPHERAL NORADRENALINE NEURONS [J].

JONSSON, G ;

HALLMAN, H ;

PONZIO, F ;

ROSS, S .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 72 (2-3) :173-188

[9] THE STRUCTURE OF CEREBRAL-CORTEX IN THE RAT FOLLOWING PRENATAL ADMINISTRATION OF 6-HYDROXYDOPAMINE [J].

LIDOV, HGW ;

MOLLIVER, ME .

DEVELOPMENTAL BRAIN RESEARCH, 1982, 3 (01) :81-108

[10] DISTRIBUTION OF VASOACTIVE INTESTINAL POLYPEPTIDE IN THE RAT AND MOUSE-BRAIN [J].

LOREN, I ;

EMSON, PC ;

FAHRENKRUG, J ;

BJORKLUND, A ;

ALUMETS, J ;

HAKANSON, R ;

SUNDLER, F .

NEUROSCIENCE, 1979, 4 (12) :1953-1976