HIGH-OUTPUT HEART-FAILURE IN MITOCHONDRIAL MYOPATHY - A FULMINANT FORM WITH SEVERE LACTIC-ACIDOSIS AND RHABDOMYOLYSIS

被引：7

作者：

HIROSE, Y

MIIDA, T

YOSHIDA, K

KIMURA, H

ODA, H

TOEDA, T

HIGUMA, N

机构：

[1] The Critical Care Medical Center, Niigata City General Hospital, Niigata

[2] The Department of Cardiology, Niigata City General Hospital, Niigata

[3] The Department of Nephrology, Niigata City General Hospital, Niigata

来源：

INTERNAL MEDICINE | 1993年 / 32卷 / 10期

关键词：

NADH-COENZYME-Q REDUCTASE (COMPLEX-I) DEFICIENCY; ACUTE RENAL FAILURE; BLOOD PURIFICATION; SHOSHIN BERIBERI;

D O I：

10.2169/internalmedicine.32.798

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 17-year-old male with mitochondrial myopathy was transferred to our hospital because of respiratory distress and a rapidly deteriorating level of consciousness. He had a markedly increased cardiac output with low systemic vascular resistance and decreased arteriovenous oxygen difference. Severe lactic acidosis, rhabdomyolysis and acute renal failure were also present. He was treated in the intensive care unit with continuous hemofiltration and hemodialysis. This case demonstrates that cardiac failure in mitochondrial encephalomyopathy may be caused by myocardial abnormalities as well as by reduced systemic vascular resistance secondary to disturbed oxidative metabolism.

引用

页码：798 / 801

页数：4

共 16 条

[1]

Shapira Y., Hard S., Russell A., Mitochondrial encephalomyopathies, Isr J Med, 13, (1977)

[2]

Tanaka H., Secondary cardiomyopathy associated with myopathy, Nippon Naika Gakkai Zasshi, 80, (1991)

[3]

Tohyama J., Torigoe K., Sato S., Et al., A case of complex I deficiency with episodic respiratory distress, No to Hattatsu, 22, (1990)

[4]

Goto Y., Tojo M., Tohyama J., Horai S., Nonaka I., A novel point mutation in the mitochondrial tRNALeu(UUR) gene in a family with mitochondrial myopathy, Ann Neurol, 31, (1992)

[5]

Tojo M., Ogawa N., Takeuchi M., Et al., Ergometric and pathologic study of a family with complex I deficiency, No to Hattatsu, 24, (1992)

[6]

Przyrembel H., Therapy of mitochondrial disorders, J Inherit Metab Dis, 10, (1987)

[7]

Morgan-Hughes J.A., Darveniza P., Landon D.N., Land J.M., Clark J.B., A mitochondrial myopathy with a deficiency of respiratory chain NADH-CoQ reductase activity, J Neurol Sci, 43, (1979)

[8]

Ichiki T., Tanaka M., Nishikimi M., Et al., Deficiency of subunits of complex I and mitochondrial encephalomyopathy, Ann Neurol, 23, (1988)

[9]

Sengers R.C.A., Stadhouders A.M., Lakwijk-Vondrovicova E., Kubat K., Ruitenbeek W., Hypertrophic cardiomyopathy associated with a mitochondrial myopathy of voluntary muscles and congenital cataract, Br Heart J, 54, (1985)

[10]

Nishizawa M., Tanaka K., Shinozawa K., Et al., A mitochondrial encephalomyopathy with cardiomyopathy, J Neuro Sci, 78, (1987)

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