ENHANCED RESPONSES OF RAT DORSAL HORN NEURONS AFTER UV IRRADIATION OF THE HINDPAW - ROLES OF THE NMDA RECEPTOR

被引：12

作者：

CHAPMAN, V ^{[1
]}

DICKENSON, AH ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL, DEPT PHARMACOL, LONDON WC1E 6BT, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

基金：

英国医学研究理事会;

关键词：

RAT; DORSAL HORN; UV IRRADIATION; A-BETA-FIBER; NMDA RECEPTOR;

D O I：

10.1016/0304-3940(94)90866-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recordings were made from nociceptive dorsal horn neurones in the anaesthetized rat 3 and 5 days after ultraviolet (UV) irradiation of the hindpaw. The electrically evoked A beta-fibre-evoked responses from the paw were enhanced and their thresholds were lowered. Spontaneous neuronal activity was increased but the C-fibre-evoked responses were unaltered. These enhanced responses, suggestive of allodynia, were reduced by N-methyl-D-aspartate receptor (NMDA) antagonism.

引用

页码：41 / 44

页数：4

共 14 条

[1] EVIDENCE FOR INVOLVEMENT OF N-METHYLASPARTATE RECEPTORS IN WIND-UP OF CLASS-2 NEURONS IN THE DORSAL HORN OF THE RAT
DAVIES, SN
LODGE, D
[J]. BRAIN RESEARCH, 1987, 424 (02) : 402 - 406
[2] DICKENSON AH, 1994, PROG PAIN RES MANAG, V1, P173
[3] ANTAGONISM AT THE GLYCINE SITE ON THE NMDA RECEPTOR REDUCES SPINAL NOCICEPTION IN THE RAT
DICKENSON, AH
AYDAR, E
[J]. NEUROSCIENCE LETTERS, 1991, 121 (1-2) : 263 - 266
[4] ACTIVITY-DEPENDENT NEURONAL PLASTICITY FOLLOWING TISSUE-INJURY AND INFLAMMATION
DUBNER, R
RUDA, MA
[J]. TRENDS IN NEUROSCIENCES, 1992, 15 (03) : 96 - 103
[5] LONG-TERM INCREASE IN CGRP LEVELS IN RAT SPINAL DORSAL HORN FOLLOWING SKIN ULTRAVIOLET-IRRADIATION - A MECHANISM OF SUNBURN PAIN
GILLARDON, F
SCHROCK, H
MORANO, I
ZIMMERMANN, M
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 657 : 493 - 496
[6] McMahon S B, 1993, Curr Opin Neurobiol, V3, P602, DOI 10.1016/0959-4388(93)90062-4
[7] ANTINOCICEPTIVE ACTIVITY OF THE BRADYKININ B1 AND B2 RECEPTOR ANTAGONISTS, DES-ARG9, [LEU8]-BK AND HOE 140, IN 2 MODELS OF PERSISTENT HYPERALGESIA IN THE RAT
PERKINS, MN
CAMPBELL, E
DRAY, A
[J]. PAIN, 1993, 53 (02) : 191 - 197
[8] PERKINS MN, 1993, J PHYSIOL-LONDON, V459, pP205
[9] INTERACTIONS BETWEEN EXCITATORY AMINO-ACIDS AND TACHYKININS IN THE RAT SPINAL DORSAL HORN
RUSIN, KI
JIANG, MC
CERNE, R
RANDIC, M
[J]. BRAIN RESEARCH BULLETIN, 1993, 30 (3-4) : 329 - 338
[10] MODULATION OF NEUROPATHIC PAIN BEHAVIOR IN RATS BY SPINAL DISINHIBITION AND NMDA RECEPTOR BLOCKADE OF INJURY DISCHARGE
SELTZER, Z
COHN, S
GINZBURG, R
BEILIN, BZ
[J]. PAIN, 1991, 45 (01) : 69 - 75

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