MASSIVE ISOTRETINOIN INTOXICATION

被引：14

作者：

AUBIN, S ^{[1
]}

LORETTE, G ^{[1
]}

MULLER, C ^{[1
]}

VAILLANT, L ^{[1
]}

机构：

[1] UNIV TOURS,MED CTR,DEPT DERMATOL,F-37044 TOURS,FRANCE

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1995年 / 20卷 / 04期

关键词：

D O I：

10.1111/j.1365-2230.1995.tb01341.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously. We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.

引用

页码：348 / 350

页数：3

共 12 条

[1] PHARMACOKINETICS OF THE RETINOIDS ISOTRETINOIN AND ETRETINATE - A COMPARATIVE REVIEW [J].