DISCRIMINATION OF SPERMIDINE AMINO FUNCTIONS BY A NEW PROTECTING GROUP STRATEGY APPLICATION TO THE SYNTHESIS OF GUANIDINYLATED POLYAMINES, INCLUDING HIRUDONINE

被引：21

作者：

MITCHINSON, A ^{[1
]}

GOLDING, BT ^{[1
]}

GRIFFIN, RJ ^{[1
]}

OSULLIVAN, MC ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 22期

关键词：

D O I：

10.1039/c39940002613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Agmatine and hirudonine, guanidine derivatives of putrescine and spermidine, respectively, are synthesised by the application of a new protecting group strategy for polyamines, which uses N-nitroguanidinyl as a precursor of guanidine functions and selectively blocks spermidine at N-1 and N-8 with trifluoroacetyl and at N-4 by 4-azidobenzyloxycarbonyl.

引用

页码：2613 / 2614

页数：2

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