ANALGESIC EFFECT OF DIOCLEA-GRANDIFLORA CONSTITUENTS IN RODENTS

被引：18

作者：

BATISTA, JS ^{[1
]}

ALMEIDA, RN ^{[1
]}

BHATTACHARYYA, J ^{[1
]}

机构：

[1] UNIV FED PARAIBA,TECNOL FARMACEUT LAB,BR-58051970 JOAO PESSOA,PARAIBA,BRAZIL

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 45卷 / 03期

关键词：

DIOCLEA GRANDIFLORA; ANALGESIC EFFECT; DIOCLEIN; OPIOID AGONIST;

D O I：

10.1016/0378-8741(94)01217-N

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.

引用

页码：207 / 210

页数：4

共 6 条

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