SYNTHESES, CRYSTAL-STRUCTURES, AND ANTITUMOR ACTIVITIES OF DINUCLEAR PLATINUM(II) COMPLEXES, DI-MU-SULFOACETATO-BIS[(DIAMINE)PLATINUM(II)] TRIHYDRATE

被引：11

作者：

MIYAMOTO, TK

ICHIDA, H

机构：

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 06期

关键词：

D O I：

10.1246/bcsj.64.1835

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new dinuclear platinum(II) complexes have been prepared from the reaction of [PtL2(OH)2] with sulfoacetic acid: [PtL2(slac)]2.3H2O, where slac = sulfoacetate dianion; L2 = 1,2-diaminocyclohexane (1a-1c) or 1,2-diaminoethane (2) and L = isopropylamine (3) or ammine (4). They have di-mu-carboxylato bridged dinuclear zwitterionic structures in crystals. Among them, complexes (1a-1c) show significant antitumor activities against mice ieukemia L1210.

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页码：1835 / 1839

页数：5

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