DEVELOPMENT OF RESISTANCE TO CIPROFLOXACIN IN NUTRIENT-RICH AND NUTRIENT-LIMITED GROWTH-CONDITIONS INVITRO BY PSEUDOMONAS-AERUGINOSA ISOLATES FROM PATIENTS WITH CYSTIC-FIBROSIS

被引：8

作者：

FERGUSON, MI ^{[1
]}

SCOTT, EM ^{[1
]}

COLLIER, PS ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH PHARM,CTR MED BIOL,97 LISBURN RD,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 12期

关键词：

D O I：

10.1128/AAC.35.12.2649

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Five serial exposures of mucoid Pseudomonas aeruginosa from patients with cystic fibrosis to subinhibitory concentrations of ciprofloxacin resulted in stepwise increases in the MIC, with a mean proportional increase of 10. MICs were significantly lower in an iron-limited chemically defined medium than in Iso-Sensitest broth. The mucoid phenotype was maintained in chemically defined medium. Acquired resistance was retained either partially or completely in 85% of the isolates following 10 transfers in drug-free media. In cases in which susceptibility was regained, an increase in the MIC was observed on one further exposure to ciprofloxacin.

引用

页码：2649 / 2651

页数：3

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