THE VASCULAR E-SELECTIN BINDS TO THE LEUKOCYTE INTEGRINS CD11/CD18

被引：76

作者：

KOTOVUORI, P

TONTTI, E

PIGOTT, R

SHEPHERD, M

KISO, M

HASEGAWA, A

RENKONEN, R

NORTAMO, P

ALTIERI, DC

GAHMBERG, CG

机构：

[1] UNIV HELSINKI, DEPT BIOCHEM, UNIONINKATU 35, SF-00170 HELSINKI 17, FINLAND

[2] BRITISH BIOTECHNOL LTD, OXFORD, ENGLAND

[3] GIFU UNIV, DEPT APPL BIOORGAN CHEM, GIFU, JAPAN

[4] UNIV HELSINKI, DEPT BACTERIOL & IMMUNOL, SF-00100 HELSINKI, FINLAND

[5] SCRIPPS RES INST, LA JOLLA, CA USA

来源：

GLYCOBIOLOGY | 1993年 / 3卷 / 02期

基金：

芬兰科学院;

关键词：

ADHESION; INTEGRINS; LEUKOCYTE; SELECTIN;

D O I：

10.1093/glycob/3.2.131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Le(x) carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.

引用

页码：131 / 136

页数：6

共 65 条

[1]

ALTIERI DC, 1991, J IMMUNOL, V147, P1891

[2]

ARNAOUT MA, 1990, BLOOD, V75, P1037

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