CIRCADIAN CARBAMAZEPINE TOXICITY

被引：5

作者：

HAEFELI, WE

MEYER, PG

LUSCHER, TF

机构：

[1] UNIV BASEL HOSP,DEPT INTERNAL MED,DIV CLIN PHARMACOL,CH-4031 BASEL,SWITZERLAND

[2] CANTONAL HOME ELDERLY,DEPT PSYCHIAT,LIESTAL,SWITZERLAND

来源：

EPILEPSIA | 1994年 / 35卷 / 02期

关键词：

ANTICONVULSANTS; TOXIC EFFECTS; PHARMACEUTICAL CHEMISTRY; CENTRAL NERVOUS SYSTEM; CIRCADIAN RHYTHM;

D O I：

10.1111/j.1528-1157.1994.tb02451.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Owing to marked fluctuations in plasma concentrations, circadian CNS toxicity (maximum in the early afternoon) occurred in a 69-year-old female patient being treated with an instant-release formulation of carbamazepine (CBZ). The neurologic syndrome was reversible after administration of the same daily dose as sustained-release formulation. This case illustrates the importance of correct timing of blood sampling to detect drug-induced toxicity and of use of sustained-release formulations in antiepileptic therapy with CBZ.

引用

页码：400 / 402

页数：3

共 9 条

[1]

CANGER R, 1990, ACTA NEUROL SCAND, V82, P9

[2]

HOPPENER RJ, 1980, EPILEPSIA, V21, P341

[3] USEFULNESS OF BLOOD-LEVELS OF ANTIEPILEPTIC DRUGS [J].