BIOCOMPATIBILITY OF BIODEGRADABLE AND NONBIODEGRADABLE POLYMER-COATED STENTS IMPLANTED IN PORCINE PERIPHERAL ARTERIES

被引：37

作者：

DESCHEERDER, IK

WILCZEK, KL

VERBEKEN, EV

VANDORPE, J

LAN, PN

SCHACHT, E

PIESSENS, J

DEGEEST, H

机构：

[1] Department of Cardiology, University Hospital Gasthuisberg, Leuven, B-3000

[2] Department of Pathology, University Hospital Gasthuisberg, Leuven, B-3000

[3] Department of Organic Chemistry, Biomaterial Research Group, University of Ghent, Ghent, B-9000

来源：

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | 1995年 / 18卷 / 04期

关键词：

ENDOVASCULAR STENTS; POLYMER; BIOCOMPATIBILITY; THROMBOGENICITY; NEOINTIMAL FOREIGN BODY REACTION;

D O I：

10.1007/BF00239417

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries. Methods: Nonarticulated, stainless steel, slotted-tube stents were coated with 1) a biodegradable poly(organo)phosphazene with aminoacid ester side, groups and 2) a biostable polyurethane prepared from an amphiphilic polyether, diphenyl methane-4,4'-diisocyanate and butane diol as chain extender. The stents were deployed in porcine peripheral arteries using an oversized balloon. Results: The neointimal response to amphiphilic polyurethane-coated stents was similar to the uncoated metallic stents. Poly(organo)phosphazene-coated stents, however, induced a severe histiolymphocytic and fibromuscular reaction resembling a foreign body reaction. Conclusions: Amphiphilic polyurethane is very promising as a biocompatible stent coating. Poly(organo)phosphazene, however, appears unsuitable for this purpose.

引用

页码：227 / 232

页数：6

共 21 条

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