PLASMA-LEVELS OF IL-1, TNF-ALPHA, IL-6, IL-8, G-CSF, AND IL1-RA DURING FEBRILE NEUTROPENIA - RESULTS OF A PROSPECTIVE-STUDY IN PATIENTS UNDERGOING CHEMOTHERAPY FOR ACUTE MYELOGENOUS LEUKEMIA

被引：8

作者：

SCHONBOHN, H ^{[1
]}

SCHULER, M ^{[1
]}

KOLBE, K ^{[1
]}

PESCHEL, C ^{[1
]}

HUBER, C ^{[1
]}

BEMB, W ^{[1
]}

AULITZKY, WE ^{[1
]}

机构：

[1] UNIV HOSP MAINZ,DEPT INTERNAL MED 3,DIV HEMATOL,DEPT MICROBIOL,D-55131 MAINZ,GERMANY

来源：

ANNALS OF HEMATOLOGY | 1995年 / 71卷 / 04期

关键词：

PLASMA LEVELS; INTERLEUKIN; NEUTROPENIA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.

引用

页码：161 / 168

页数：8

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