TUMOR-CELL PROLIFERATION IN RELATION TO VASCULATURE

被引：137

作者：

HIRST, DG

DENEKAMP, J

机构：

[1] Gray Laboratory of the Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex

来源：

CELL AND TISSUE KINETICS | 1979年 / 12卷 / 01期

关键词：

D O I：

10.1111/j.1365-2184.1979.tb00111.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proliferation pattern of a transplantable mouse mammary carcinoma has been studied in relation to its macroscopic and microscopic structure. No significant differences were seen in the labelling or mitotic indices or in the percentage labelled mitoses curves for the peripheral 2‐0 mm rim or for the central tumour core. When these parameters were scored for cells classified according to their position in relation to capillaries or to necrotic regions, marked differences were observed in all the parameters. Higher labelling and mitotic indices and higher grain counts were seen adjacent to the capillaries. These appear to result from a shorter cell cycle duration and a higher growth fraction. The variation in cell cycle is mainly due to a change in the duration of G1. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：31 / 42

页数：12

共 19 条

[1] RELATIONSHIP BETWEEN CELL LOSS FACTOR AND IMMEDIATE RESPONSE TO RADIATION IN ANIMAL TUMORS [J].