HUMAN CYP1A1 (CYTOCHROME-P(1)450) GENE - LACK OF ASSOCIATION BETWEEN THE MSP-I RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND INCIDENCE OF LUNG-CANCER IN A NORWEGIAN POPULATION

被引：190

作者：

TEFRE, T ^{[1
]}

RYBERG, D ^{[1
]}

HAUGEN, A ^{[1
]}

NEBERT, DW ^{[1
]}

SKAUG, V ^{[1
]}

BROGGER, A ^{[1
]}

BORRESEN, AL ^{[1
]}

机构：

[1] NORWEGIAN RADIUM HOSP,DEPT GENET,N-0310 OSLO 3,NORWAY

来源：

PHARMACOGENETICS | 1991年 / 1卷 / 01期

关键词：

D O I：

10.1097/00008571-199110000-00004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study of 221 lung cancer patients and 212 controls, no association between a Msp I polymorphism in the CYP1A1 gene and an increased risk of lung cancer was found. Histological type, smoking habits and family history were also examined. No associations between the Msp I restriction fragment length polymorphism in the CYP1A1 gene and any of these parameters were found. These results are in contrast to a previous report by a Japanese group (Kawajiri et al., 1990) who found an association between the less common allele and an increased susceptibility to lung cancer in their population. The frequency of the less common Msp I 1.9 kb fragment allele (C2) appears to be three times greater in the Japanese population than in the Norwegian population and a Caucasian population of North America. It is possible that in the Asian population this Msp I polymorphism is in linkage disequilibrium with another mutation important for CYP1A1 gene expression, whereas in the Caucasian population these mutations are in equilibrium.

引用

页码：20 / 25

页数：6

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