EFFECTS OF ARSENIC ON DNA-SYNTHESIS IN HUMAN-LYMPHOCYTES

被引：16

作者：

MENG, ZQ

机构：

来源：

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 1993年 / 25卷 / 04期

关键词：

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Effects of arsenic on DNA synthesis in human lymphocytes were biphasic: Either trivalent (arsenic trioxide and sodium arsenite) or pentavalent (sodium arsenate) arsenic compounds at very low concentrations enhanced DNA synthesis in human lymphocytes stimulated by phytohemagglutinin (PHA), whereas higher concentrations inhibited DNA synthesis. There were differences among individual susceptibities to arsenic-induced DNA synthesis. Either stimulating or inhibiting effects of trivalent arsenic on DNA synthesis in PHA-stimulated lymphocytes were always stronger than those of pentavalent arsenic. Both trivalent and pentavalent arsenic could be rapidly taken up into the human lymphocytes and immediately stimulate or inhibit DNA synthesis. A possible dual effect of arsenic at very low concentrations as both comutagen and inhibitor of mutagenesis is discussed.

引用

页码：525 / 528

页数：4

共 26 条

[1] ALTERATION IN PROTEIN-SYNTHESIS IN PRIMARY CULTURES OF RAT-KIDNEY PROXIMAL TUBULE EPITHELIAL-CELLS BY EXPOSURE TO GALLIUM, INDIUM, AND ARSENITE [J].