FIBRONECTIN ATTACHMENT IS PERMISSIVE FOR IL-1 MEDIATED GENE-REGULATION

被引：24

作者：

OSTBERG, CO ^{[1
]}

ZHU, P ^{[1
]}

WIGHT, TN ^{[1
]}

QWARNSTROM, EE ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

来源：

FEBS LETTERS | 1995年 / 367卷 / 01期

关键词：

FIBRONECTIN; INTEGRIN; CYTOKINE; GENE REGULATION;

D O I：

10.1016/0014-5793(95)00509-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examines the effect of cell-matrix interaction on IL-1 induced gene regulation. In fibroblasts and smooth muscle cells attached to fibronectin, IL-1 caused a pronounced reduction in proteoglycan synthesis, while no reduction occurred in cells plated on bare plastic. Further, fibronectin attachment was permissive for IL-1 mediated suppression of both versican and collagen mRNA levels, initially noted after 4-6 h of IL-1 incubation. Attachment to vitronectin was less potent in influencing regulation, and collagen had no effect, suggesting specificity of the matrix modulation of the IL-1 induced response. Similar fibronectin induced dependence was demonstrated for IL-1 regulation of IL-6 gene expression, supporting the notion of a general effect of fibronectin receptor engagement on IL-1 induced signal transduction.

引用

页码：93 / 97

页数：5

共 36 条

[1] INTERLEUKIN-1-INDUCED CALCIUM FLUX IN HUMAN FIBROBLASTS IS MEDIATED THROUGH FOCAL ADHESIONS [J].