2 CLASSES OF PDGF RECEPTOR RECOGNIZE DIFFERENT ISOFORMS OF PDGF

Previous studies involving platelet-derived growth factor (PDGE) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptors as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.