GENETIC SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS

被引：42

作者：

VISSCHER, BR ^{[1
]}

DETELS, R ^{[1
]}

DUDLEY, J ^{[1
]}

HAILE, RW ^{[1
]}

MALMGREN, RM ^{[1
]}

TERASAKI, PI ^{[1
]}

PARK, MS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT SURG, LOS ANGELES, CA 90024 USA

来源：

NEUROLOGY | 1979年 / 29卷 / 10期

关键词：

D O I：

10.1212/WNL.29.10.1354

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous studies of histocompatibility (HLA) types in multiple sclerosis (MS) families did not provide convincing proof of an HLA-linked susceptibility factor. In 12 families we studied, all MS cases in each family shared at least one chromosome. The probability of this occurring in the absence of genetic linkage is approximately 0.001. The estimated penetrance is 5 percent, implying that the genetic susceptibility factor may be a necessary but not a sufficient cause of MS. Additional studies are needed to identify other differences between affected and unaffected susceptible individuals. © 1979 American Academy of Neurology.

引用

页码：1354 / 1360

页数：7

共 20 条

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