ONCHOCERCACIDAL EFFECTS OF AMOCARZINE (CGP-6140) IN LATIN-AMERICA

被引：27

作者：

POLTERA, AA

ZEAFLORES, G

GUDERIAN, R

BELTRANENA, F

PROANA, R

MORAN, M

ZAK, F

STRIEBEL, HP

机构：

[1] MINIST HLTH,DEPT ONCHOCERCIASIS,GUATEMALA CITY,GUATEMALA

[2] MINIST HLTH,ONCHOCERCIASIS CONTROL PROJECT,QUITO,ECUADOR

[3] RODOLFO ROBLES HOSP,DEPT OPHTHALMOL,GUATEMALA CITY,GUATEMALA

[4] HOSP VOZANDES,DEPT OPHTHALMOL,QUITO,ECUADOR

来源：

LANCET | 1991年 / 337卷 / 8741期

关键词：

D O I：

10.1016/0140-6736(91)91642-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An open clinical trial of amocarzine was carried out in onchocerciasis patients in Ecuador and Guatemala. Administration after food was more effective than that during fasting. The most effective and best tolerated regimen, 3 mg/kg twice daily after food for 3 days (in 312 patients), killed 73% of 1477 female worms at nodulectomy 4 months after treatment. The mean microfilarial skin count was greatly reduced within a week (6-11% of day 0 value on day 8) and it remained low for at least 6 months (14-18% on day 180). Follow-up of a higher dose 3 day regimen taken while fasting showed microfilaridermia of 7-9% of the day 0 value 2 years after treatment.

引用

页码：583 / 584

页数：2

共 9 条

[1] LACK OF ADVERSE REACTIONS IN IVERMECTIN TREATMENT OF ONCHOCERCIASIS [J].