THE INTERACTION BETWEEN HPV INFECTION AND ESTROGEN METABOLISM IN CERVICAL CARCINOGENESIS

被引：89

作者：

AUBORN, KJ

WOODWORTH, C

DIPAOLO, JA

BRADLOW, HL

机构：

[1] NCI,BETHESDA,MD 20892

[2] INST HORMONE RES,NEW YORK,NY 10016

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 49卷 / 06期

关键词：

D O I：

10.1002/ijc.2910490611

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer of the genital tract is the final outcome of some infections with human papillomavirus (HPVs), and the most estrogen-sensitive cells are at greatest risk for the HPV-related cancers. Therefore we investigated relationships between HPVs and estrogen metabolism in cells of the genital tract. Increased conversion of estradiol to 16-alpha-hydroxyestrone, known to be a risk factor for cancer in some other estrogen-sensitive cells, was investigated in keratinocytes from the genital tract. Primary cells, particularly those explants from the transformation zone of the cervix, are able to 16-alpha-hydroxylate estradiol. Both cervical and foreskin cells immortalized with HPV-16 are greatly enhanced in the 16-alpha-a-hydroxylation of estradiol as compared with normal cells. We suggest a model whereby the combined action of 16-alpha-hydroxylation of estrogen and HPV work together to promote cell proliferation.

引用

收藏

页码：867 / 869

页数：3

相关论文

共 33 条

[1] ESTRADIOL 16-ALPHA-HYDROXYLATION IN THE MOUSE CORRELATES WITH MAMMARY-TUMOR INCIDENCE AND PRESENCE OF MURINE MAMMARY-TUMOR VIRUS - A POSSIBLE MODEL FOR THE HORMONAL ETIOLOGY OF BREAST-CANCER IN HUMANS [J].

BRADLOW, HL ;

HERSHCOPF, RJ ;

MARTUCCI, CP ;

FISHMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (18) :6295-6299

[2] 16-ALPHA-HYDROXYLATION OF ESTRADIOL - A POSSIBLE RISK MARKER FOR BREAST-CANCER [J].

BRADLOW, HL ;

HERSHCOPF, R ;

MARTUCCI, C ;

FISHMAN, J .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 464 :138-151

[3] PROGESTERONE AND GLUCOCORTICOID RESPONSE ELEMENTS OCCUR IN THE LONG CONTROL REGIONS OF SEVERAL HUMAN PAPILLOMAVIRUSES INVOLVED IN ANOGENITAL NEOPLASIA [J].

CHAN, WK ;

KLOCK, G ;

BERNARD, HU .

JOURNAL OF VIROLOGY, 1989, 63 (08) :3261-3269

[4] PHOSPHORYLATION OF THE RETINOBLASTOMA GENE-PRODUCT IS MODULATED DURING THE CELL-CYCLE AND CELLULAR-DIFFERENTIATION [J].

CHEN, PL ;

SCULLY, P ;

SHEW, JY ;

WANG, JYJ ;

LEE, WH .

CELL, 1989, 58 (06) :1193-1198

[5] HUMAN PAPILLOMAVIRUS TYPE-16 COOPERATES WITH ACTIVATED RAS AND FOS ONCOGENES IN THE HORMONE-DEPENDENT TRANSFORMATION OF PRIMARY MOUSE CELLS [J].

CROOK, T ;

STOREY, A ;

ALMOND, N ;

OSBORN, K ;

CRAWFORD, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :8820-8824

[6] THE HUMAN PAPILLOMA VIRUS-16 E7-ONCOPROTEIN IS ABLE TO BIND TO THE RETINOBLASTOMA GENE-PRODUCT [J].

DYSON, N ;

HOWLEY, PM ;

MUNGER, K ;

HARLOW, E .

SCIENCE, 1989, 243 (4893) :934-937

[7] BIOLOGICAL PROPERTIES OF 16 ALPHA-HYDROXYESTRONE - IMPLICATIONS IN ESTROGEN PHYSIOLOGY AND PATHO-PHYSIOLOGY [J].

FISHMAN, J ;

MARTUCCI, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 51 (03) :611-615

[8] INCREASED ESTROGEN-16-ALPHA-HYDROXYLASE ACTIVITY IN WOMEN WITH BREAST AND ENDOMETRIAL CANCER [J].

FISHMAN, J ;

SCHNEIDER, J ;

HERSHCOPF, RJ ;

BRADLOW, HL .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1984, 20 (4B) :1077-1081

[9] ENHANCEMENT OF 2-ALPHA-ESTRADIOL AND 16-ALPHA-ESTRADIOL HYDROXYLATION IN MCF-7 HUMAN-BREAST CANCER-CELLS BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN [J].

GIERTHY, JF ;

LINCOLN, DW ;

KAMPCIK, SJ ;

DICKERMAN, HW ;

BRADLOW, HL ;

NIWA, T ;

SWANECK, GE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (02) :515-520

[10]

Gissmann L, 1987, PAPILLOMAVIRUSES HUM, p467~ 503

← 1 2 3 4 →