EFFECT OF PERTURBING DIACYLGLYCEROL METABOLISM ON CYTOSOLIC FREE CA-2+ OSCILLATIONS INDUCED IN SINGLE HEPATOCYTES

被引：4

作者：

SANCHEZBUENO, A ^{[1
]}

COBBOLD, PH ^{[1
]}

机构：

[1] UNIV LIVERPOOL, DEPT HUMAN ANAT & CELL BIOL, POB 147, LIVERPOOL L69 3BX, ENGLAND

来源：

FEBS LETTERS | 1992年 / 312卷 / 01期

基金：

英国惠康基金;

关键词：

CA-2+ OSCILLATION; DIACYLGLYCEROL; R-59-022; DIC8; SINGLE HEPATOCYTE;

D O I：

10.1016/0014-5793(92)81409-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single rat hepatocytes microinjected with aequorin show free Ca oscillations when stimulated with Ca2+-mobilizing hormones. We show here that an inhibitor of diacylglycerol kinase (R 59 022) and an analogue of native diacylglycerol (diC-8) inhibit free Ca oscillations induced by phenylephrine and vasopressin. These results agree with a negative feedback effect of protein kinase C on free Ca oscillations.

引用

页码：57 / 60

页数：4

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