SUBCUTANEOUS INJECTION OF AN ANALOG OF NEUROPEPTIDE-FF PRECIPITATES MORPHINE ABSTINENCE SYNDROME

被引：12

作者：

MALIN, DH

LAKE, JR

ARCANGELI, KAR

DESHOTEL, KD

HAUSAM, DD

WITHERSPOON, WE

CARTER, VA

YANG, HYT

PAL, B

BURGESS, K

机构：

[1] ST ELIZABETH HOSP, NIMH, CTR NEUROSCI, WASHINGTON, DC 20032 USA

[2] TEXAS A&M UNIV SYST, DEPT CHEM, COLL STN, TX 77843 USA

来源：

LIFE SCIENCES | 1993年 / 53卷 / 17期

关键词：

D O I：

10.1016/0024-3205(93)90601-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats. but not in sham controls.

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收藏

页码：PL261 / PL266

页数：6

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