ELECTROENCEPHALOGRAPHIC AND AUTONOMIC RESPONSES TO TRICHLOROETHYLENE INHALATION IN FREELY MOVING RATS

被引:5
作者
ARITO, H [1 ]
TAKAHASHI, M [1 ]
SOTOYAMA, M [1 ]
TSURUTA, H [1 ]
ISHIKAWA, T [1 ]
机构
[1] KITASATO UNIV, SCH HYGIEN SCI, SAGAMIHARA 238, JAPAN
关键词
TRICHLOROETHYLENE; SLEEP-WAKEFULNESS; HEART RATE; BRADYARRHYTHMIA; SLEEP APNEA;
D O I
10.1007/BF01973307
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Effects of trichloroethylene (TRI) on the central nervous system (CNS) and autonomic functions were examined by means of continuous polygraphic measurements of electroencephalogram (EEG), electromyogram (EMG) and electrocardiogram (ECG) in electrode-implanted and freely moving rats, while they were exposed via inhalation to TRI vapor of 300, 1000 or 3000 ppm for 8 h/day or 6000 ppm for 4 h/day on 3 consecutive days. The exposures to 3000 and 6000 ppm produced abnormal EEG activity and,incapacitation of postural maintenance during the exposure period, while the post-exposure period was characterized by decreased waking (W) time, lowered heart rate (HR) and increased numbers of bradyarrhythmic episodes after recovery from anesthesia. The exposure to 1000 ppm decreased W time without the appearance of anesthesia. The exposure to 300 ppm did not produce any observable effects except the lowered HR, which occurred during the post-exposure period. The relationships between internal doses of TRI and its metabolites and these TRI-induced pathophysiological responses were determined by blood and brain analyses of TRI, trichloroethanol and trichloroacetic acid in the TRI-exposed rats. Recordings of respiratory chest wall movement revealed that the number of TRI-induced bradyarrhythmias accompanying apnea during paradoxical sleep (PS) increased significantly after cessation of exposure to 6000 ppm TRI. This suggests that TRI-induced hypoxemia due to apnea during PS triggers bradyarrhythmogenesis through increased cardiac vagal efferent tone.
引用
收藏
页码:193 / 199
页数:7
相关论文
共 34 条
[1]   ACUTE OXYGEN IN PATIENTS WITH SLEEP-APNEA AND COPD [J].
ALFORD, NJ ;
FLETCHER, EC ;
NICKESON, D .
CHEST, 1986, 89 (01) :30-38
[2]  
[Anonymous], 1971, STAT PRINCIPLES EXPT
[3]   CHANGES IN SLEEP AND WAKEFULNESS FOLLOWING SINGLE AND REPEATED EXPOSURES TO TOLUENE VAPOR IN RATS [J].
ARITO, H ;
TSURUTA, H ;
OGURI, M .
ARCHIVES OF TOXICOLOGY, 1988, 62 (01) :76-80
[4]  
ARITO H, 1990, TOXICOL LETT, V52, P169
[5]  
BACHMAN DS, 1973, PEDIATRICS, V51, P755
[6]   TECHNIQUE FOR VAGAL STIMULATION IN CHRONIC EXPERIMENTS [J].
BACHMAN, DS .
JOURNAL OF APPLIED PHYSIOLOGY, 1972, 33 (03) :402-&
[7]  
BARDODEJ JZ, 1955, AMA ARCH IND HLTH, V13, P581
[8]   ARRHYTHMIAS DOCUMENTED BY 24-HOUR CONTINUOUS ELECTROCARDIOGRAPHIC MONITORING IN 50 MALE MEDICAL-STUDENTS WITHOUT APPARENT HEART-DISEASE [J].
BRODSKY, M ;
WU, D ;
DENES, P ;
KANAKIS, C ;
ROSEN, KM .
AMERICAN JOURNAL OF CARDIOLOGY, 1977, 39 (03) :390-395
[9]   NONANOXIC AEROSOL ARRHYTHMIAS [J].
FLOWERS, NC ;
HORAN, LG .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1972, 219 (01) :33-&
[10]  
GUILLEMINAULT C, 1980, AM REV RESPIR DIS, V122, P397