STEROIDS AND RELATED STUDIES .44. 17A-METHYL-3BETA-(N-PYRROLIDINYL)-17A-AZA-D-HOMO-5ALPHA-ANDROSTANE BIS-(METHIODIDE) (DIHYDROCHANDONIUM IODIDE) AND CERTAIN OTHER ANALOGS OF CHANDONIUM IODIDE

被引：43

作者：

SINGH, H

BHARDWAJ, TR

AHUJA, NK

PAUL, D

机构：

[1] Department of Pharmaceutical Sciences, Panjab University

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 02期

关键词：

D O I：

10.1039/p19790000305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bisquaternary analogues 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D- homo-5α-androstane bismethiodide (dihydrochandonium iodide) (4), 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5α-androstane bisethiodide (5), 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homoandrost-5- ene bisethiodide (2), and 17a-ethyl-3β-(N-pyrrolidinyl)-17a-aza-D- homoandrost-5-ene bisethiodide (3) related to chandonium iodide (1) have been prepared. 5,6-Saturation and increase in Onium bulk decrease the neuromuscular blocking potency; however, dihydrochandonium iodide (4) appears to be a promising compound for further study.

引用

页码：305 / 307

页数：3

共 12 条

[1]

ANLIKER R, 1955, HELV CHIM ACTA, V38, P1404, DOI 10.1002/hlca.19550380611

[2] RESEARCHES ON ACETYLENIC COMPOUNDS .1. THE PREPARATION OF ACETYLENIC KETONES BY OXIDATION OF ACETYLENIC CARBINOLS AND GLYCOLS [J].