THE USE OF PROBENECID TO INCREASE THE SERUM AMOXYCILLIN LEVELS IN PATIENTS WITH BRONCHIECTASIS

被引：5

作者：

ALLEN, MB ^{[1
]}

FITZPATRICK, RW ^{[1
]}

BARRATT, A ^{[1
]}

COLE, RB ^{[1
]}

机构：

[1] CITY GEN HOSP,STOKE ON TRENT ST4 6QG,STAFFS,ENGLAND

来源：

RESPIRATORY MEDICINE | 1990年 / 84卷 / 02期

关键词：

D O I：

10.1016/S0954-6111(08)80018-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amoxycillin 3 g twice daily is effective in treating patients with bronchiectasis who have daily purulent sputum. However, it is a relatively expensive treatment if used for prolonged periods. This pilot study in six patients with bronchiectasis showed that the concurrent administration of probenecid with a smaller dose of amoxycillin produced similar clinical responses and pharmacokinetic profiles to those found with high dose amoxycillin alone. The amount of amoxycillin used was reduced by two thirds, producing a potential saving of approximately $1000 per patient per annum in those taking long term treatment. © 1990, Baillière Tindall. All rights reserved.

引用

页码：143 / 146

页数：4

共 10 条

[1]

BARBHAIYA R, 1979, BRIT J VENER DIS, V55, P211

[2] PROBENECID - ANTIBACTERIAL ACTION AGAINST NEISSERIA-GONORRHOEAE AND INTERACTION WITH BENZYLPENICILLIN [J].