FLUOROMETRIC AND LIQUID-CHROMATOGRAPHIC STUDY OF THE BINDING OF 2 COUMARINS TO BETA-CYCLODEXTRIN

被引：13

作者：

KARNIK, NA ^{[1
]}

PRANKERD, RJ ^{[1
]}

PERRIN, JH ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL PHARM,BOX J494,GAINESVILLE,FL 32610

来源：

CHIRALITY | 1991年 / 3卷 / 02期

关键词：

ENANTIOMERS; WARFARIN; PHENPROCOUMON; COMPLEXES; HPLC; FLUORESCENT ENHANCEMENT;

D O I：

10.1002/chir.530030208

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The fluorescences of warfarin and phenprocoumon are enhanced following complexation with beta-cyclodextrin; (+)-(R)- and (-)-(S)-phenprocoumons have different affinities for this cyclodextrin, whereas the corresponding enantiomers of warfarin have similar binding constants. Apparently, hemiketal formation in the case of warfarin minimizes chiral discrimination. This is confirmed using a beta-cyclodextrin bonded chromatography column on which the phenprocoumon enantiomers are separated, whereas those of warfarin are not.

引用

页码：124 / 128

页数：5

共 15 条

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