THE STEREOSPECIFIC PREPARATION OF AN HYDROXYETHYLENE ISOSTERE PRECURSOR VIA A NOVEL PIPERIDINE-2,5-DIONE TEMPLATE

被引：19

作者：

PLATA, DJ

LEANNA, MR

MORTON, HE

机构：

[1] Process chemistry research, pharmaceutical products division abbott laboratories, Abbott Park

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)79750-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydroxyethylene isostere precursor 2 was synthesized by stereochemical manipulation of a novel keto-lactam ''template''. The final product was prepared in very high enantiomeric purity, in 23% overall yield from L-phenylalanine.

引用

页码：3623 / 3626

页数：4

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