G-PROTEINS ARE INVOLVED IN THE REGULATION OF TRANSMITTER RELEASE AT AN APLYSIA CHOLINERGIC SYNAPSE

被引：6

作者：

BAUX, G

FOSSIER, P

TAUC, L

机构：

来源：

BRAIN RESEARCH | 1992年 / 575卷 / 01期

关键词：

G-PROTEIN; ACETYLCHOLINE RELEASE; CALCIUM CURRENT; SYNAPSE; APLYSIA; ELECTROPHYSIOLOGY;

D O I：

10.1016/0006-8993(92)90437-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

At an identified cholinergic synapse of the Aplysia buccal ganglion, presynaptic injections of guanosine 5'-O-3-thiotriphosphate (GTP-gamma-S) depressed the amplitude of evoked postsynaptic responses. This reduction of acetylcholine (ACh) release by GTP-gamma-S, prevented by preinjection of guanosine 5'-O-2-thiodiphosphate (GDP-beta-S) in the presynaptic neuron, was due to a reduction of the number of ACh quanta released. The mean amplitude of the evoked miniature postsynaptic current (MPSC) was unchanged. The presynaptic Ca2+ influx was lowered.

引用

收藏

页码：155 / 158

页数：4

相关论文

共 43 条

[1] 2 ENDOGENOUS NEUROPEPTIDES MODULATE THE GILL AND SIPHON WITHDRAWAL REFLEX IN APLYSIA BY PRESYNAPTIC FACILITATION INVOLVING CAMP-DEPENDENT CLOSURE OF A SEROTONIN-SENSITIVE POTASSIUM CHANNEL [J].

ABRAMS, TW ;

CASTELLUCCI, VF ;

CAMARDO, JS ;

KANDEL, ER ;

LLOYD, PE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (24) :7956-7960

[2] CA-2+-STIMULATED CATECHOLAMINE RELEASE FROM ALPHA-TOXIN-PERMEABILIZED PC12 CELLS - BIOCHEMICAL-EVIDENCE FOR EXOCYTOSIS AND ITS MODULATION BY PROTEIN-KINASE-C AND KINASE-G PROTEINS [J].

AHNERTHILGER, G ;

BRAUTIGAM, M ;

GRATZL, M .

BIOCHEMISTRY, 1987, 26 (24) :7842-7848

[3] CALCIUM DEPENDENCE OF PRESYNAPTIC CALCIUM CURRENT AND POSTSYNAPTIC RESPONSE AT THE SQUID GIANT SYNAPSE [J].

AUGUSTINE, GJ ;

CHARLTON, MP .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 381 :619-640

[4] HISTAMINE AND FLRFAMIDE REGULATE ACETYLCHOLINE-RELEASE AT AN IDENTIFIED SYNAPSE IN APLYSIA IN OPPOSITE WAYS [J].

BAUX, G ;

FOSSIER, P ;

TAUC, L .

JOURNAL OF PHYSIOLOGY-LONDON, 1990, 429 :147-168

[5] RECEPTOR-EFFECTOR COUPLING BY G-PROTEINS [J].

BIRNBAUMER, L ;

ABRAMOWITZ, J ;

BROWN, AM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1031 (02) :163-224

[6]

BLEY KR, 1990, NEURON, V2, P379

[7] SUPPRESSION OF CALCIUM CURRENT BY AN ENDOGENOUS NEUROPEPTIDE IN NEURONS OF APLYSIA-CALIFORNICA [J].

BREZINA, V ;

ECKERT, R ;

ERXLEBEN, C .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 388 :565-595

[8] GUANOSINE 5'-TRIPHOSPHATE ANALOG ACTIVATES POTASSIUM CURRENT MODULATED BY NEUROTRANSMITTERS IN APLYSIA NEURONS [J].

BREZINA, V .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 407 :15-40

[9] MODULATION OF POTASSIUM CONDUCTANCES BY AN ENDOGENOUS NEUROPEPTIDE IN NEURONS OF APLYSIA-CALIFORNICA [J].

BREZINA, V ;

ECKERT, R ;

ERXLEBEN, C .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 382 :267-290

[10]

BROWN AM, 1991, NEWS PHYSIOL SCI, V6, P158

← 1 2 3 4 5 →