2 NEW PROCEDURES FOR THE INTRODUCTION OF BENZYL-TYPE PROTECTING GROUPS FOR THIOLS

被引：21

作者：

RICHTER, LS

MARSTERS, JC

GADEK, TR

机构：

[1] Department of Bioorganic Chemistry Genentech, Inc., South San Francisco, CA 94080

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 11期

关键词：

D O I：

10.1016/0040-4039(94)88305-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new methods for the benzylation of thiols are described: a) direct S-alkylation with para-substituted benzylic cations; and b) reductive S-alkylations of 2-aminothiols. Both methods provide efficient routes for the introduction of benzyl-type protecting groups in high yields.

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页码：1631 / 1634

页数：4

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