DIFFERENTIAL NEURONAL-ACTIVITY IN SEGMENTS OF GLOBUS-PALLIDUS IN PARKINSONS-DISEASE PATIENTS

被引:235
作者
HUTCHISON, WD
LOZANO, AM
DAVIS, KD
SAINTCYR, JA
LANG, AE
DOSTROVSKY, JO
机构
[1] UNIV TORONTO,FAC MED,DEPT ANAT & CELL BIOL,TORONTO M5S 1A8,ON,CANADA
[2] UNIV TORONTO,FAC MED,DEPT PSYCHOL,TORONTO M5S 1A8,ON,CANADA
[3] TORONTO WESTERN HOSP,DIV NEUROSURG,TORONTO M5T 2S8,ON,CANADA
[4] TORONTO WESTERN HOSP,DIV NEUROL,TORONTO M5T 2S8,ON,CANADA
关键词
PARKINSONS DISEASE; BASAL GANGLIA; GLOBUS PALLIDUS; STEREOTAXIC SURGERY; MICROELECTRODES;
D O I
10.1097/00001756-199407000-00031
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
MICROELECTRODE trajectories through the globus pallidus of 6 Parkinson's disease (PD) patients yielded neurophysiological 'landmarks' which enabled the identification of neurones located in the external segment (GPe) and internal segments, exterior (GPi,e) and interior (GPi,i) of globus pallidus and the surrounding borders (Bor). Firing rate histograms and inter-spike interval time histograms were constructed for neurones in each region. The neuronal activity in GPi,i was higher than in the other segments, and a high degree of bursting was found in GPe and GPi neurones. This profile of neuronal activity is similar to that observed in monkeys treated with MPTP, suggesting that the observed level of activity of neurones in GPi,i is excessive, and contributes to the bradykinesia and rigidity of PD patients.
引用
收藏
页码:1533 / 1537
页数:5
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