FREE-RADICAL SCAVENGER DEPLETION IN POSTISCHEMIC REPERFUSION BRAIN-DAMAGE

被引：69

作者：

VANELLA, A ^{[1
]}

DIGIACOMO, C ^{[1
]}

SORRENTI, V ^{[1
]}

RUSSO, A ^{[1
]}

CASTORINA, C ^{[1
]}

CAMPISI, A ^{[1
]}

RENIS, M ^{[1
]}

PEREZPOLO, JR ^{[1
]}

机构：

[1] DEPT HUMAN BIOL CHEM & GEN,GALVESTON,TX

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 12期

关键词：

ISCHEMIA; REPERFUSION; SCAVENGER; GSH-DEPLETORS; SURVIVAL;

D O I：

10.1007/BF00975056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study the influence of pretreatment with various GSH depletors such as buthionine sulfoximine (BSO) and diethylmaleate (DEM) was investigated in rats following cerebral postischemic reperfusion. Moreover, the effect of diethyldithiocarbamic acid (DDC), inhibitor of endogenous Cu,Zn-SOD, was evaluated. A significant depletion (40% of control value) of GSH levels was observed 24 h after DEM administration; after 48 h the value reached control levels. BSO showed maximal GSH depletion (59%) 24 h after administration and it was constant for almost 48 h. DDC administration caused a marked decrease (60%) of Cu,Zn-SOD activity 4 h after the injection and induced a marked decrease in percentage of survival with respect to control (untreated, ischemic) rats, when administered 4 h before ischemia. BSO and DEM prolonged the survival time of animals when administered 24 h before ischemia. This last paradoxical effect is unclear at present, but it might be due to an influence on glutamate cascade.

引用

页码：1337 / 1340

页数：4

共 26 条

[1] SPIN TRAPPING OF OXYGEN AND CARBON-CENTERED FREE-RADICALS IN ISCHEMIC CANINE MYOCARDIUM [J].