MEL-18, A POLYCOMB GROUP-RELATED MAMMALIAN GENE, ENCODES A TRANSCRIPTIONAL NEGATIVE REGULATOR WITH TUMOR SUPPRESSIVE ACTIVITY

被引：118

作者：

KANNO, M ^{[1
]}

HASEGAWA, M ^{[1
]}

ISHIDA, A ^{[1
]}

ISONO, K ^{[1
]}

TANIGUCHI, M ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT SURG 2,CHUO KU,CHIBA 260,JAPAN

来源：

EMBO JOURNAL | 1995年 / 14卷 / 22期

关键词：

MEL-18; BMI-1; POLYCOMB GROUP; TRANSCRIPTIONAL NEGATIVE REGULATOR; TUMOR SUPPRESSOR;

D O I：

10.1002/j.1460-2075.1995.tb00254.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian mel-18/bmi-1 gene products share an amino acid sequence and a secondary structure, including a RING-finger motif, with the Drosophila Polycomb group (PcG) gene products Psc and Su(z)2, implying that they represent a gene family with related functions, As Drosophila PcG gene products are thought to function as transcriptional repressors by modifying chromatin structure, Mel-18/Bmi-1 might be expected to have similar activities, Here we have analyzed the function of mel-18 and found that Mel-18 acts as a transcriptional repressor via its target DNA sequence, 5'-GACTNGACT-3', Interestingly, this binding sequence is found within regulatory or non-coding regions of various genes, including the c-myc, bcl-2 and Hox genes, suggesting diverse functions of mel-18 as the mammalian homolog of the PcG gene, We also demonstrate that mel-18 has tumor suppressor activity, in contrast to bmi-1, which has been defined as a protooncogene.

引用

页码：5672 / 5678

页数：7

共 35 条

[1] APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2 [J].