DIFFERENCE IN RESPONSE OF D-2 RECEPTOR-BINDING BETWEEN C-11 N-METHYLSPIPERONE AND C-11 RACLOPRIDE AGAINST ANESTHETICS IN RHESUS-MONKEY BRAIN

被引：39

作者：

KOBASASHI, K

INOUE, O

WATANABE, Y

ONOE, H

LANGSTROM, B

机构：

[1] NIPPON MED COLL,DEPT NEUROPHYSIOL,TOKYO,JAPAN

[2] OSAKA BIOSCI INST,DEPT NEUROSCI,OSAKA,JAPAN

[3] RES DEV CORP JAPAN,SUBFEMTOMOLE BIORECOGNIT PROJECT,OSAKA,JAPAN

[4] UPPSALA UNIV,PET CTR,UPPSALA,SWEDEN

[5] NATL INST RADIOL SCI,DIV CLIN RES & RADIAT HLTH,INAGE KU,CHIBA 263,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1995年 / 100卷 / 02期

关键词：

PET; ANESTHETICS; KETAMINE; ISOFLURANE; DOPAMINE D-2 RECEPTOR; MONKEY;

D O I：

10.1007/BF01271537

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of anesthesia on dopamine D-2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of C-11-N-methylspiperone (NMSP) and C-11-raclopride (RAG) were measured under controlled ketamine or isoflurane anesthesia. The binding of C-11-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of C-11-RAC than of C-11-NMSP. These findings suggest that changes in C-11-NMSP or C-11-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.

引用

页码：147 / 151

页数：5

共 8 条

[1]

COENEN HH, 1988, EUR J NUCL MED, V14, P80

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