HETEROCYCLIC SYSTEMS WITH A BRIDGEHEAD NITROGEN .2. 6-CHLOROIMIDAZO[2,1-B]THIAZOLE AND SOME OF ITS 5-SUBSTITUTED DERIVATIVES

被引：38

作者：

PAOLINI, JP

LENDVAY, LJ

机构：

[1] National Drug Company, Research Laboratories, Division of Richardson-Merrell Inc., Philadelphia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 06期

关键词：

D O I：

10.1021/jm00306a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of 3-carboxymethyl-2-iminothiazoline and POCl3 gives 6-chloroimidazo[2,1-b] thiazole. This system undergoes electrophilic substitution at the 5 position, as shown by means of nmr analysis. Some of these compounds demonstrated antiinflammatory and antihypertensive activity. © 1969, American Chemical Society. All rights reserved.

引用

页码：1031 / &

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