QUANTITATIVE SELECTED ION MONITORING ASSAY FOR KETOPROFEN DETERMINATION IN HUMAN BIOLOGICAL-FLUIDS

被引：7

作者：

DEGRAEVE, J

FRANKINET, C

GIELEN, JE

机构：

[1] Laboratoire de Chimie Médicale, Université de Liège, Institut de Pathologie, Unité de Biochimie, Liège

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 06期

关键词：

D O I：

10.1002/bms.1200060605

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new very sensitive method of ketoprofen [(benzoyl‐3‐phenyl)2‐propionic acid] determination in various biological fluids using selected ion monitoring is described. After ether extraction in acidic medium, ketoprofen and (benzoyl‐4‐phenyl)‐2‐butyric acid used as internal standard are methylated and their concentrations determined by monitoring the m/z values corresponding to their respective molecular ions. Standard deviation is below 5% at 100 ng ml−1. Detection limits range from 10 ng ml−1 for urine and serum samples to 50 ng ml−1 for maternal milk specimens. This method has been applied successfully to various biological studies: pharmacokinetic profiles, bioavailability and transfer of the drug through physiological barriers. Copyright © 1979 Heyden & Son Ltd

引用

页码：249 / 252

页数：4

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