WHOLE MOUSE NITROXIDE FREE-RADICAL PHARMACOKINETICS BY LOW-FREQUENCY ELECTRON-PARAMAGNETIC RESONANCE

被引：59

作者：

FERRARI, M

COLACICCHI, S

GUALTIERI, G

SANTINI, MT

SOTGIU, A

机构：

[1] IST SUPER SANITA,BIOL CELLULAIRE DEPT A,I-00161 ROME,ITALY

[2] IST NAZL FIS NUCL,SEZIONE SANITA,ROME,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91926-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vivo uptake distribution and reduction of the oxygen-sensitive nitroxide spin label PCA in the mouse monitored by low frequency electron paramagnetic resonance (EPR) spectroscopy are reported. Spectra were obtained from the head and liver regions of pentobarbital anesthetized mice during different circulatory and ventilatory conditions. Identical clearances were found in these regions during normoxia. Moderate hypoxia (10% O2-90% N2) did not significantly affect the spin label reduction rate. © 1990.

引用

页码：168 / 173

页数：6

共 17 条

[1] NITROXYL SPIN LABEL CONTRAST ENHANCERS FOR MAGNETIC-RESONANCE IMAGING - STUDIES OF ACUTE TOXICITY AND MUTAGENESIS [J].