HEPATIC-CLEARANCE MEASUREMENTS AND PHARMACOKINETICS

被引：25

作者：

KEIDING, S

ANDREASEN, PB

机构：

来源：

PHARMACOLOGY | 1979年 / 19卷 / 03期

关键词：

D O I：

10.1159/000137296

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review emphasizes the need for well-defined models for hepatic pharmacokinetics and discusses the interpretation of hepatic clearance measurements. Such recent approaches are subjected to theoretical and experimental comparisons. The pharmacokinetic consequences, including a classification of drugs according to hepatic clearance, are outlined.

引用

页码：105 / 110

页数：6

共 26 条

[1]

ANDREASEN B, 1977, ACTA PHARMACOL TOX, V40, P1

[2]

ARNOLD K, 1970, CLIN PHARMACOL THER, V11, P121

[3] HEPATIC ELIMINATION OF FLOWING SUBSTRATES - DISTRIBUTED MODEL [J].