LDL-INDUCED AND AGONIST-INDUCED CA2+-MOBILIZATION IN PLATELETS OF HEALTHY-SUBJECTS AND IN PATIENTS WITH FAMILIAL HYPERLIPOPROTEINEMIA TYPE-II

被引：10

作者：

BOCHKOV, VN

ROZHKOVA, TA

MATCHIN, YG

LYAKISHEV, AA

BOCHKOVA, NA

BORISOVA, YL

KUKHARCHUK, VV

TKACHUK, VA

机构：

[1] Cardiology Research Center, the USSR, Moscow

来源：

THROMBOSIS RESEARCH | 1991年 / 61卷 / 04期

关键词：

PLATELETS; CALCIUM; HYPERLIPOPROTEINEMIA;

D O I：

10.1016/0049-3848(91)90654-F

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

LDL induced a reversible increase in [Ca2+]i in platelets of healthy subjects and FH-patients. In both groups the effects of LDL were potentiated 2.3-fold by epinephrine. [Ca2+]i increases, induced by LDL, ADP and PAF were more prominent in platelets of FH-patients. This may explain the platelet hyperaggregability in such conditions.

引用

页码：403 / 409

页数：7

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