RU-486 INTERFERES WITH EGG TRANSPORT AND RETARDS THE INVIVO AND INVITRO DEVELOPMENT OF MOUSE EMBRYOS

被引：17

作者：

YANG, YQ ^{[1
]}

WU, JT ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT OBSTET & GYNECOL,55 LAKE AVE N,WORCESTER,MA 01655

来源：

CONTRACEPTION | 1990年 / 41卷 / 05期

关键词：

D O I：

10.1016/0010-7824(90)90063-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Oral administration of RU 486 at 100 mg/kg BW/day to mice on Days 1 and 2 of pregnancy caused retention of embryos in the oviduct and expulsion of those having entered the uterus. The treatment also retarded the development of embryos. In vitro study showed that RU 486 reduced the percentage of 2-cell mouse embryos developing into blastocysts. Thus, in addition to interfering with egg transport and impairing embryonic development in vivo, RU 486 can act directly on the embryo, interfering with preimplantation development in vitro. © 1990.

引用

页码：551 / 556

页数：6

共 12 条

[1] THE EFFECTS OF THE PROGESTERONE ANTAGONIST RU-486 ON MOUSE PREIMPLANTATION DEVELOPMENT INVITRO AND INVIVO [J].

BATTEN, BE ;

ROH, SI ;

KIM, MH .

CONTRACEPTION, 1988, 38 (03) :365-371

[2] TERMINATION OF EARLY-PREGNANCY BY THE PROGESTERONE ANTAGONIST RU-486 (MIFEPRISTONE) [J].

COUZINET, B ;

LESTRAT, N ;

ULMANN, A ;

BAULIEU, EE ;

SCHAISON, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (25) :1565-1570

[3] OVUM TRANSPORT IN PREGNANT RATS IS LITTLE AFFECTED BY RU486 AND EXOGENOUS PROGESTERONE AS COMPARED TO CYCLING RATS [J].

FUENTEALBA, B ;

NIETO, M ;

CROXATTO, HB .

BIOLOGY OF REPRODUCTION, 1987, 37 (04) :768-774

[4] SPECIES DIFFERENCES IN EGG TRANSPORT IN RESPONSE TO EXOGENOUS ESTROGEN [J].

GREENWALD, GS .

ANATOMICAL RECORD, 1967, 157 (02) :163-+

[5] THE PROGESTERONE ANTAGONIST RU-486 - A POTENTIAL NEW CONTRACEPTIVE AGENT [J].

NIEMAN, LK ;

CHOATE, TM ;

CHROUSOS, GP ;

HEALY, DL ;

MORIN, M ;

RENQUIST, D ;

MERRIAM, GR ;

SPITZ, IM ;

BARDIN, CW ;

BAULIEU, EE ;

LORIAUX, DL .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (04) :187-191

[6]

PSYCHOYOS A, 1987, J REPROD FERTIL, V80, P487

[7]

ROBEL P, 1985, ANTIPROGESTIN STEROI, P295

[8] THE EFFECT OF RU486 ON TRANSPORT, DEVELOPMENT AND IMPLANTATION OF MOUSE EMBRYOS [J].

ROBLERO, LS ;

FERNANDEZ, O ;

CROXATTO, HB .

CONTRACEPTION, 1987, 36 (05) :549-555

[9] INTERCEPTION .3. POSTCOITAL LUTEAL CONTRAGESTION BY AN ANTIPROGESTIN (MIFEPRISTONE, RU-486) IN 62 WOMEN [J].

VANSANTEN, MR ;

HASPELS, AA .

CONTRACEPTION, 1987, 35 (05) :423-431

[10] ACTION OF ANTI-PROGESTERONE MONOCLONAL-ANTIBODY IN BLOCKING PREGNANCY AFTER POSTCOITAL ADMINISTRATION IN MICE [J].

WANG, MY ;

RIDER, V ;

HEAP, RB ;

FEINSTEIN, A .

JOURNAL OF ENDOCRINOLOGY, 1984, 101 (01) :95-+

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