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EOSINOPHILIC AIRWAY INFLAMMATION DURING EXACERBATION OF ASTHMA AND ITS TREATMENT WITH INHALED CORTICOSTEROID

被引：108
作者：
LAITINEN, LA
LAITINEN, A
HEINO, M
HAAHTELA, T
机构：
[1] CENT MIL HOSP,MIL MED RES INST,HELSINKI,FINLAND
[2] UNIV HELSINKI,DEPT ELECTRON MICROSCOPY,SF-00100 HELSINKI 10,FINLAND
[3] UNIV HELSINKI,CENT HOSP,DEPT PULM MED,SF-00100 HELSINKI 10,FINLAND
[4] UNIV HELSINKI,CENT HOSP,DEPT ALLERG DIS,SF-00100 HELSINKI 10,FINLAND
[5] UNIV LUND,DEPT LUNG MED,S-22101 LUND,SWEDEN
来源：
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1991年 / 143卷 / 02期
关键词：
D O I：
10.1164/ajrccm/143.2.423
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
We have compared the inflammatory changes in the bronchial mucosa and the increase in the airway hyperresponsiveness in an asthmatic patient during the deterioration of symptoms. A striking increase in the number of bronchial epithellal eosinophils was associated with an increase in both airway hyperresponsiveness and asthma symptoms. During 16 wk of treatment with the inhaled corticosteroid, budesonide, the patient's clinical status and airway hyperresponsiveness improved. This was accompanied by an improvement in the ultrastructure of bronchial mucosa and a decrease in the number of epithelial eosinophils.
引用
收藏
页码：423 / 427
页数：5
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