A NOVEL TARGETED DELIVERY SYSTEM UTILIZING A CEPHALOSPORIN-ONCOLYTIC PRODRUG ACTIVATED BY AN ANTIBODY BETA-LACTAMASE CONJUGATE FOR THE TREATMENT OF CANCER

被引:56
作者
SHEPHERD, TA [1 ]
JUNGHEIM, LN [1 ]
MEYER, DL [1 ]
STARLING, JJ [1 ]
机构
[1] HYBRITECH INC,DIV THERAPEUT,SAN DIEGO,CA 92121
关键词
D O I
10.1016/S0960-894X(01)81083-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Cephalosporins substituted at C-3' with oncolytic agents such as vinca alkaloids have been developed as prodrugs for the treatment of solid tumors. Conversion of prodrug to drug is mediated by an immunoconjugate consisting of a beta-lactamase enzyme covalently attached to a monoclonal antibody Fab' fragment which is pre-localized at the tumor.
引用
收藏
页码:21 / 26
页数:6
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