A NOVEL TARGETED DELIVERY SYSTEM UTILIZING A CEPHALOSPORIN-ONCOLYTIC PRODRUG ACTIVATED BY AN ANTIBODY BETA-LACTAMASE CONJUGATE FOR THE TREATMENT OF CANCER

被引：56

作者：

SHEPHERD, TA ^{[1
]}

JUNGHEIM, LN ^{[1
]}

MEYER, DL ^{[1
]}

STARLING, JJ ^{[1
]}

机构：

[1] HYBRITECH INC,DIV THERAPEUT,SAN DIEGO,CA 92121

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)81083-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cephalosporins substituted at C-3' with oncolytic agents such as vinca alkaloids have been developed as prodrugs for the treatment of solid tumors. Conversion of prodrug to drug is mediated by an immunoconjugate consisting of a beta-lactamase enzyme covalently attached to a monoclonal antibody Fab' fragment which is pre-localized at the tumor.

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页码：21 / 26

页数：6

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