SYNTHESIS OF 2,4-DIDEOXY-BETA-D-ERYTHRO-HEXOPYRANOSYL NUCLEOSIDES

被引：41

作者：

AUGUSTYNS, K ^{[1
]}

ROZENSKI, J ^{[1
]}

VANAERSCHOT, A ^{[1
]}

JANSSEN, G ^{[1
]}

HERDEWIJN, P ^{[1
]}

机构：

[1] REGA INST,MED CHEM LAB,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 11期

关键词：

D O I：

10.1021/jo00063a013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (12)1 was accomplished using two different synthetic routes. It was obtained starting either from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose or from tri-O-acetyl-D-glucal. The other modified nucleosides, with either a cytosine, guanine, or adenine moiety, were synthesized using the second reaction scheme. Deoxygenation reactions were accomplished with the (2,4-dichlorophenoxy)thiocarbonyl derivatives generated in situ.

引用

页码：2977 / 2982

页数：6

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